Matos, Maria João Correia Pinto Carvalho deVázquez Rodríguez, SaletaBorges, FernandaUriarte Villares, Eugenio2021-08-192021-08-192010Proceedings of the 14th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2010, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-14-003763-906980-24-3http://hdl.handle.net/10347/26872With the aim to find out the best methodology to prepare different series of substituted coumarins, thinking on their pharmacological evaluation, in the present communication we report the synthesis of 3-phenylcoumarin with different number and position of substituent groups in both 3-phenyl and coumarin rings. The substituents in this new scaffold were introduced in the 6 and 8 positions of the coumarin moiety and in 3'and 4' positions of the 3-phenyl ring. The synthesized compounds 1-7, 8 and 9-11 were prepared and characterized by different methodologies. Perkin modified reaction (method A and B) and Palladium-catalyzed synthesis (method C) were the methodologies described in this communicationeng© 2010 The author(s). Published by MDPI, Basel, Switzerland. Open Access3-ArylcoumarinsPalladium-catalyzed synthesisPerkin reactionbook part10.3390/ecsoc-14-00376open access