Rodrigues Amorim, DanielaRivera Baltanás, TaniaVallejo Curto, María del CarmenRodríguez Jamardo, CynthiaHeras, Elena de lasBarreiro Villar, CarolinaBlanco Formoso, MaríaFernández Palleiro, PatriciaÁlvarez Ariza, MaríaLópez García, MartaGarcía Caballero, Alejandro AlbertoOlivares Díez, José ManuelSpuch, Carlos2020-04-072020-04-072019Rodrigues-Amorim D, Rivera-Baltanás T, Vallejo-Curto MdC, Rodriguez-Jamardo C, de las Heras E, Barreiro-Villar C, Blanco-Formoso M, Fernández-Palleiro P, Álvarez-Ariza M, López M, García-Caballero A, Olivares JM and Spuch C (2019) Proteomics in Schizophrenia: A Gateway to Discover Potential Biomarkers of Psychoneuroimmune Pathways. Front. Psychiatry 10:885. doi: 10.3389/fpsyt.2019.00885http://hdl.handle.net/10347/21228Schizophrenia is a severe and disabling psychiatric disorder with a complex and multifactorial etiology. The lack of consensus regarding the multifaceted dysfunction of this ailment has increased the need to explore new research lines. This research makes use of proteomics data to discover possible analytes associated with psychoneuroimmune signaling pathways in schizophrenia. Thus, we analyze plasma of 45 patients [10 patients with first-episode schizophrenia (FES) and 35 patients with chronic schizophrenia] and 43 healthy subjects by label-free liquid chromatography–tandem mass spectrometry. The analysis revealed a significant reduction in the levels of glia maturation factor beta (GMF- β), the brain-derived neurotrophic factor (BDNF), and the 115-kDa isoform of the Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) in patients with schizophrenia as compared to healthy volunteers. In conclusion, GMF-β, BDNF, and 115-kDa isoform of RAB3GAP1 showed significantly reduced levels in plasma of patients with schizophrenia, thus making them potential biomarkers in schizophrenia.engCopyright © 2019 Rodrigues-Amorim, Rivera-Baltanás, Vallejo-Curto, Rodriguez- Jamardo, de las Heras, Barreiro-Villar, Blanco-Formoso, Fernández-Palleiro, Álvarez- Ariza, López, García-Caballero, Olivares and Spuch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these termshttps://creativecommons.org/licenses/by/4.0/SchizophreniaProteomicsLiquid chromatography–tandem mass spectrometryRab3 GTPaseactivating protein catalytic subunitGlia maturation factor betaBrain-derived neurotrophic factorjournal article10.3389/fpsyt.2019.008851664-0640open access