Mosquera Mosquera, JesúsRodríguez Villar, JéssicaVázquez Sentís, Marco EugenioMascareñas Cid, José Luis2014-12-052017-08-292014-04-24Mosquera, J., Rodríguez, J., Vázquez, M. E. and Mascareñas, J. L. (2014), Selective DNA-Binding by Designed Bisbenzamidine-Homeodomain Chimeras. ChemBioChem, 15: 1092–1095. doi: 10.1002/cbic.2014000791439-7633http://hdl.handle.net/10347/11967We report the construction of conjugates between three variants of the helix 3 region of a Q50K engrailed homeodomain and bisbenzamidine minor-groove DNA binders. The hybrid featuring the sequence of the native protein failed to bind to DNA; however, modifications that increased the α-helical folding propensity of the peptide allowed specific DNA binding by a bipartite (major/minor groove) interactioneng© WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimDNA recognitionMolecular recognitionOligonucleotidesPeptidesSupramolecular chemistryMaterias::Investigación::23 Química::2302 Bioquímicajournal article10.1002/cbic.201400079open access