Vargas Osorio, ZulemaLuzardo Álvarez, Asteria MaríaPiñeiro Redondo, YolandaVázquez Vázquez, CarlosGómez Amoza, José LuisBlanco Méndez, JoséOtero Espinar, Francisco JavierRivas Rey, José2020-04-132020-04-132019Vargas-Osorio, Z., Luzardo-Álvarez, A., Piñeiro, Y., Vázquez-Vázquez, C., Gómez-Amoza, J.L., Blanco-Méndez, J., Otero Espinar, F.J., Rivas, J. (2019) Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility. "ACS Omega", 4 (3), 5496-5508http://hdl.handle.net/10347/21348The development of scaffolds with suitable physicochemical and mechanical properties allowing for the structural regeneration of injured bone and recovery of the natural biological functionality is still a challenge in the tissue engineering field. Nanostructured materials with added theranostic abilities, together with an interconnected hierarchy of pores, offer the possibility to provide a new generation of bone implants. In this work, scaffolds with highly porous and resistant threedimensional structures have been successfully developed by homogeneously embedding mesoporous silica nanostructures in a bioactive matrix of chitosan/κ-carrageenan. Moreover, magnetite (Fe3O4) nanoparticles were also added to the mesoporous scaffold to include additional magnetic functionalities for diagnostic or therapeutic actions. The complete physicochemical characterization shows mesoporous materials with a wide range of interconnected pores, remarkable surface roughness, and large effective surface area, suitable for cell adhesion. In accordance to these properties, a simvastatin loading and release assay showed high loading capacities and sustained release over a long period of time. Together with a suitable resistance against degradation and biocompatible performance assessed by cell viability assays, these scaffolds show interesting features for delivering drugs with activity in bone regeneration processes.engCopyright © 2019 American Chemical Society. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposesjournal article10.1021/acsomega.8b036762470-1343open access