Simões, Ana RitaFernández Rozadilla, CeresMaroñas Amigo, OlallaCarracedo Álvarez, Ángel2020-12-162020-12-162020Simões, A.R.; Fernández-Rozadilla, C.; Maroñas, O.; Carracedo, Á. The Road so Far in Colorectal Cancer Pharmacogenomics: Are We Closer to Individualised Treatment? J. Pers. Med. 2020, 10, 237http://hdl.handle.net/10347/24035In recent decades, survival rates in colorectal cancer have improved greatly due to pharmacological treatment. However, many patients end up developing adverse drug reactions that can be severe or even life threatening, and that affect their quality of life. These remain a limitation, as they may force dose reduction or treatment discontinuation, diminishing treatment efficacy. From candidate gene approaches to genome-wide analysis, pharmacogenomic knowledge has advanced greatly, yet there is still huge and unexploited potential in the use of novel technologies such as next-generation sequencing strategies. This review summarises the road of colorectal cancer pharmacogenomics so far, presents considerations and directions to be taken for further works and discusses the path towards implementation into clinical practiceeng© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Colorectal cancerAdverse drug reactionsPharmacogenomicsPersonalised medicineToxicityjournal article10.3390/jpm100402372075-4426open access