Vázquez López, MiguelVázquez Sentís, Marco EugenioBarka, Ghofrane2018-02-062018-02-062017http://hdl.handle.net/10347/16429A series of Ru(II) metallopeptides featuring the dipyrido[3,2-a:2',3'-c]phenazine ligand (dppz) have been synthesized through solid-phase peptide synthesis (SPPS) methods. Spectroscopic studies indicate that functionalization with an oligoarginine basic tail causes a drastic change in the binding mode and a great increase of the affinity of these metallopeptides for well-matched B-DNA oligonucleotides over mismacthed DNAs. In addition, the spectroscopic data suggest that both the oligoarginine functionalization and the nature of the ancillary ligands do not cause an increase of the selectivity of these metallopeptides for a particular type of mismatched DNA oligonucleotide. Finally, fluorescence microscopy studies indicate that the oligoarginine functionalization causes the efficient internalization of the metallopeptides into Vero cells, causing apoptotic cell death after a few hours.engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glaminoácidosquimioterapiapéptidoscompuestos de coordinaciónMaterias::Investigación::23 Química::2302 Bioquímica::230202 AminoácidosMaterias::Investigación::23 Química::2302 Bioquímica::230206 QuimioterapiaMaterias::Investigación::23 Química::2302 Bioquímica::230224 PéptidosMaterias::Investigación::23 Química::2303 Química inorgánica::230307 Compuestos de coordinacióndoctoral thesisopen access