Suárez Suárez, SamuelDoallo Pesado, SoniaPérez García, José ManuelCorral Varela, María MontserratRodríguez Holguín, SocorroCadaveira Mahía, Fernando2020-06-092020-06-092020Suárez-Suárez, S., Doallo, S., Pérez-García, J.M., Corral, M., Rodríguez Holguín, S., Cadaveira, F. (2020). Response Inhibition and Binge Drinking During Transition to University: An fMRI Study. Frontiers in Psychiatry, 11:535. doi: 10.3389/fpsyt.2020.00535http://hdl.handle.net/10347/22915Background: Binge Drinking (BD), a highly prevalent drinking pattern among youth, has been linked with anomalies in inhibitory control. However, it is still not well characterized whether the neural mechanisms involved in this process are compromised in binge drinkers (BDs). Furthermore, recent findings suggest that exerting inhibitory control to alcohol-related stimuli requires an increased effort in BDs, relative to controls, but the brain regions subserving these effects have also been scarcely investigated. Here we explored the impact of BD on the pattern of neural activity mediating response inhibition and its modulation by the motivational salience of stimuli (alcohol-related content). Methods: Sixty-seven (36 females) first-year university students, classified as BDs (n = 32) or controls (n = 35), underwent fMRI as they performed an alcohol-cued Go/NoGo task in which pictures of alcoholic or non-alcoholic beverages were presented as Go or NoGo stimuli. Results: During successful inhibition trials, BDs relative to controls showed greater activity in the bilateral inferior frontal gyrus (IFG), extending to the anterior insula, a brain region usually involved in response inhibition tasks, despite the lack of behavioral differences between groups. Moreover, BDs displayed increased activity in this region restricted to the right hemisphere when inhibiting a prepotent response to alcohol-related stimuli. Conclusions: The increased neural activity in the IFG/insula during response inhibition in BDs, in the absence of behavioral impairments, could reflect a compensatory mechanism. The findings suggest that response inhibition-related activity in the right IFG/insula is modulated by the motivational salience of stimuli and highlight the role of this brain region in suppressing responses to substance-associated cues.engCopyright © 2020 Suárez-Suárez, Doallo, Pérez-García, Corral, Rodríguez Holguín and Cadaveira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these termshttp://creativecommons.org/licenses/by/4.0/Binge drinkingResponse inhibitionGo/NoGofMRINeuroimagingAlcohol-related stimuliConsumo intensivo de alcoholInhibición de respostaNeuroimaxeIRMfEstímulos asociados a alcoholjournal article10.3389/fpsyt.2020.005351664-0640open access