Dunster, Joanne L.Unsworth, Amanda J.Bye, Alexander P.Haining, Elizabeth J.Sowa, Marcin A.Di, YingSage, TanyaPallin, ChiaraPike, Jeremy A.Hardy, Alexander T.Nieswandt, BernhardGarcía Alonso, ÁngelWatson, Steve P.Poulter, Natalie S.Gibbins, Jonathan M.Pollitt, Alice Y.2020-04-072020-04-072019Dunster, JL, Unsworth, AJ, Bye, AP, et al. Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. J Thromb Haemost. 2020; 18: 485– 496. https://doi.org/10.1111/jth.146731538-7933http://hdl.handle.net/10347/21240Accurate protein quantification is a vital prerequisite for generating meaningful predictions when using systems biology approaches, a method that is increasingly being used to unravel the complexities of subcellular interactions and as part of the drug discovery process. Quantitative proteomics, flow cytometry, and western blotting have been extensively used to define human platelet protein copy numbers, yet for mouse platelets, a model widely used for platelet research, evidence is largely limited to a single proteomic dataset in which the total amount of proteins was generally comparatively higher than those found in human platelets.eng© 2019 The Authors and the Journal of Thrombosis and Haemostasis. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly citedhttps://creativecommons.org/licenses/by/4.0/GPVIMathematical modellingPlateletSykjournal article10.1111/jth.146731538-7836open access