González González, José ManuelCendón Mariño, BorjaMascareñas Cid, José LuisGulías Costa, Moisés2021-03-222021J. Am. Chem. Soc. 2021, 143, 10, 3747–37520002-7863http://hdl.handle.net/10347/24850Enantioenriched, six-membered azacycles are essential structural motifs in many products of pharmaceutical or agrochemical interest. Here we report a simple and practical method for enantioselective assembly of tetrahydropyridines, which is paired to a kinetic resolution of α-branched allyltriflamides. The reaction consists of a formal (4+2) cycloaddition between the allylamine derivatives and allenes and is initiated by a palladium(II)-catalyzed C–H activation process. Both the chiral allylamide precursors and the tetrahydropyridine adducts were successfully obtained in high yields, with excellent enantioselectivity (up to 99% ee) and selectivity values of up to 127eng© 2021 American Chemical Society. This is an open access article under the CC Attribution 4.0 International (CC BY 4.0) license (http://creativecommons.org/licenses/by/4.0/)http://creativecommons.org/licenses/by/4.0/journal article10.1021/jacs.1c019291520-5126open access