López López, RafaelAbal Posada, MiguelBarbazán García, JorgeUniversidade de Santiago de Compostela. Facultade de Bioloxía. Facultade de Medicina e Odontoloxía. Departamento de Medicina. Laboratorio de Oncoloxía Médica Traslacional2014-09-032014-09-032014-09-03http://hdl.handle.net/10347/11431Colorectal cancer (CRC) represents the third most diagnosed cancer type worldwide, accounting for more than 600.000 deaths in 2012, which approximately represents 8,5% of all cancer-related deaths. It arises from the inner intestinal layer, usually from preexisting polyps that, after a series of molecular and genetic alterations, finally generate colorectal tumors. It is very important to consider that in CRC patients, the appearance of cancer metastasis, tumor masses that originate from primary tumors at distant sites, strongly determine patient prognosis. Only 8-10% of patients diagnosed with CRC at advanced stages survive after five years of follow up, which reinforces the importance of metastasis research to improve patient management and survival rates in CRC.engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glColorectal cancer (CRC)Circulating tumor cells (CTCs)metastasisMaterias::Investigación::32 Ciencias médicas::3207 Patología::320713 Oncologíadoctoral thesisopen access