Novoa García, BeatrizFigueras Huerta, AntonioLemos Ramos, Manuel LuisPereiro González, Patricia2017-10-042017-10-042017http://hdl.handle.net/10347/15834Although turbot aquaculture is well established, several pathogens can affect its health status, causing important economic losses. VHSV is one of the main threats in turbot farms due to the absence of treatments and vaccines for VHSV. The first goal of this thesis was to increase the information available in public databases regarding the transcriptome sequences associated with the antiviral immune response of turbot. A microarray highly enriched in antiviral sequences was constructed using this information. This allowed us to conduct a broad transcriptome analysis of the response to VHSV infection and evaluate the activity of a DNA vaccine against VHSV. This information led us to focus our attention on certain molecules or processes affected by the vaccine/infection. This was the case for two type I interferons (IFNs), which were characterized and studied for the first time in turbot. In order to complete our knowledge about the IFNs, we also sought to investigate the role of the type II IFN (IFN-gamma).engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glRodaballoVHSVRespuesta InmuneInterferonesMaterias::Investigación::31 Ciencias agrarias::3109 Ciencias veterinarias::310903 InmunologíaMaterias::Investigación::24 Ciencias de la vida::2401 Biología animal (zoología)::240108 Genética animaldoctoral thesisopen access