Sánchez Barreiro, Alejandro, 1965-Badiola Etxaburu, IkerFernández Piñeiro, Inés2018-04-022018-04-022018http://hdl.handle.net/10347/16634The main objective of this work has been the design of a new polysaccharide functionalised nanosystem as a non-viral microRNA vector for the treatment of liver metastasis from colorectal cancer. For this purpose, we modified our previously developed span nanoparticles using polysaccharides with endothelial targeting properties and studied their ability to act as gene delivery systems. Finally, we provide an in vivo proof-of-concept of the clinical potential of these nanoparticles as a novel microRNA-based therapeutic strategy for cancer treatment.engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glNanoparticlesGene therapyPolysaccharidesmicroRNAMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320908 Preparación de medicamentosdoctoral thesisopen access