Quiñones Téllez, María del MarMartínez Grobas, EvaFernø, JohanPérez Lois, RaquelSeoane, María LuisaAl-Massadi Iglesias, Omar2021-02-152021-02-152021Int. J. Mol. Sci. 2021, 22(3), 1430; https://doi.org/10.3390/ijms22031430http://hdl.handle.net/10347/24452Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, with SIRT1 and SIRT6 shown to exert their metabolic actions in the hypothalamus, both with crucial roles in eliciting responses to dampen metabolic complications associated with obesity. Therefore, our aim is to compile the current understanding on the role of SIRT1 and SIRT6 in the hypothalamus, especially highlighting their actions on the control of energy balanceeng© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/SIRT1SIRT6Energy balanceFood intakeBody weightAdiposityType 2 diabetesObesityjournal article10.3390/ijms220314301422-0067open access