Matos, Maria João Correia Pinto Carvalho dePérez Cruz, FernandaVázquez Rodríguez, SaletaUriarte Villares, EugenioSantana Penín, María LourdesBorges, FernandaOlea Azar, Claudio2021-01-272021-01-272013Bioorganic & Medicinal Chemistry, Volume 21, Issue 13, 1 July 2013, Pages 3900-39060968-0896http://hdl.handle.net/10347/24337In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1–9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical evaluation of ADME properties of all the derivatives was also carried out. From the ORAC-FL, ESR and CV data it was concluded that these derivatives are very good antioxidants, with a very interesting hydroxyl, DPPH and superoxide radicals scavenging profiles. In particular compound 9 is the most active and effective antioxidant of the series (ORAC-FL = 13.5, capacity of scavenging hydroxyl radicals = 100%, capacity of scavenging DPPH radicals = 65.9% and capacity of scavenging superoxide radicals = 71.5%). Kinetics profile for protection fluorescein probe against peroxyl radicals by addition of antioxidant molecule 9 was also performed. Therefore, it can operate as a potential candidate for preventing or minimizing the free radicals overproduction in oxidative-stress related diseaseseng© 2013 The Authors. Published by Elsevier Ltd. Open access under CC BY licensehttp://creativecommons.org/licenses/by/3.0/3-ArylcoumarinsHydroxyl derivativesORAC-FL assaysESR assaysCV assaysAntioxidant capacityjournal article10.1016/j.bmc.2013.04.015open access