Custodio Mendoza, Jorge AntonioSendón García, RaquelRodríguez Bernaldo de Quirós, Ana IsabelLorenzo Ferreira, Rosa AntoniaCarro Díaz, Antonia María2023-01-162023-01-162022Analytica Chimica Acta 1239 (2023) 340712http://hdl.handle.net/10347/29883A simple, fast and effective direct method based on HPLC-APCI-QqQ-MS/MS has been developed to simultaneously determine four 3-monochloropropane-1,2-diol monoesters (3-MCPDE) esterified with palmitic, linoleic, stearic, and oleic acid, and two glycidyl esters (GE) with palmitic and oleic acid in margarine and olive oil using a QuEChERS approach. Factors affecting the efficiency of the extraction process were assessed, including type and amount of salt, extraction solvent, test portion amount, and clean-up sorbent. The analytical method was validated according to Food and Drug Administration (FDA) guidelines using matrix-matched calibration with internal standards and showed good results in terms of linearity (r2 > 0.9992), accuracy (80<Recovery<120%), and precision (RSD<15%). The method was successfully applied for the first time to 11 margarine samples for simultaneous analysis of 3-MCPDE and GEeng© 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/)Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/APCIFood contaminantsGlycidylHPLC method3-MCPDQuEChERSinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-096450-B-I00/ES/INNOVACIONES ANALITICAS PARA LA EVALUACION DE MARCADORES DE CALIDAD EN RELACION CON LA SEGURIDAD ALIMENTARIAjournal article10.1016/j.aca.2022.3407120003-2670open access