Raposeiras Roubín, SergioRodiño Janeiro, Bruno KotskaParadela Dobarro, BeatrizGrigorian Shamagian, LilianGarcía Acuña, José MaríaAguiar Souto, PabloJacquet Hervet, MichelReino Maceiras, María V.Álvarez, EzequielGonzález Juanatey, José Ramón2020-07-022020-07-022012Raposeiras-Roubín, S., Rodiño-Janeiro, B.K., Paradela-Dobarro, B. et al. Predictive value of advanced glycation end products for the development of post-infarction heart failure: a preliminary report. Cardiovasc Diabetol 11, 102 (2012). https://doi.org/10.1186/1475-2840-11-1021475-2840http://hdl.handle.net/10347/23081Background Since post-infarction heart failure (HF) determines a great morbidity and mortality, and given the physiopathology implications of advanced glycation end products (AGE) in the genesis of myocardial dysfunction, it was intended to analyze the prognostic value of these molecules in order to predict post-infarction HF development. Methods A prospective clinical study in patients after first acute coronary syndrome was conducted. The follow-up period was consisted in 1 year. In 194 patients consecutively admitted in the coronary unit for myocardial infarct fluorescent AGE levels were measured. The association between glycaemic parameters and the development of post-infarction HF were analyzed in those patients. Finally, we identified the variables with independent predictor value by performing a multivariate analysis of Hazard ratio for Cox regression. Results Eleven out of 194 patients (5.6%) developed HF during follow-up (median: 1.0 years [0.8 - 1.5 years]). Even though basal glucose, fructosamine and glycated haemoglobin were significant predictive factors in the univariate analysis, after being adjusted by confounding variables and AGE they lost their statistical signification. Only AGE (Hazard Ratio 1.016, IC 95%: 1.006-1.026; p<0,001), together with NT-proBNP and the infarct extension were predictors for post-infarction HF development, where AGE levels over the median value 5-fold increased the risk of HF development during follow-up. Conclusions AGE are an independent marker of post-infarction HF development risk.eng© 2012 Raposeiras-Roubín et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.http://creativecommons.org/licenses/by/2.0Advanced glycation end productsHeart failureMyocardial infarctVentricular remodellingDiabetes mellitusjournal article10.1186/1475-2840-11-102open access