Otero Espinar, Francisco JavierFernández Ferreiro, AnxoAguiar Fernández, PabloGarcía Otero, Xurxo2023-01-182023-01-182022http://hdl.handle.net/10347/29914In the present thesis, different formulations of tacrolimus for topical-ophthalmic administration have been proposed, supported by extensive preclinical studies in order to achieve a consistent basis for the treatment of ocular inflammatory diseases. On the other hand, a pharmacokinetic and distribution study of an anti-TNFα monoclonal antibody (adalimumab) injected intravitreally was also carried out, allowing to know its behavior in the eye and thus develop new administration systems.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/ocular inflammatory diseasestacrolimusadalimumabpharmacokineticsdrug deliveryMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320901 Análisis de medicamentosMaterias::Investigación::32 Ciencias médicas::3208 Farmacodinámica::320801 Absorción de medicamentosMaterias::Investigación::32 Ciencias médicas::3209 Farmacología::320990 Farmacología experimentaldoctoral thesisopen access