Lema Rodicio, Juan ManuelMauricio Iglesias, MiguelRegueira López, Alberte2020-11-092021-06-262020http://hdl.handle.net/10347/23612Biorefineries are set to become an important agent in the shift towards a circular economy due to their potential to valorise organic wastes into marketable products. Anaerobic fermentations yielding volatile fatty acids are a key process in this production scheme as their products act as intermediates between the organic wastes and the final biorefinery products. However, their product selectivity is highly influenced by the environmental conditions and the mechanisms governing the process remain unknown. In this thesis, predictive tools were developed with the objective of understanding the mechanisms governing anaerobic fermentations and of designing processes targeting specific volatile fatty acids with high productivity.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Volatile fatty acidsmixed-culture fermentationsmathematical modelsbioprocess designmechanistic insightMaterias::Investigación::33 Ciencias tecnológicas::3302 Tecnología bioquímica::330202 Tecnología de la fermentaciónMaterias::Investigación::33 Ciencias tecnológicas::3302 Tecnología bioquímica::330203 Microbiología industrialMaterias::Investigación::33 Ciencias tecnológicas::3302 Tecnología bioquímica::330290 Ingeniería bioquímicaMechanistic understanding of mixed-culture fermentations by metabolic modellingdoctoral thesisopen access