Barja Fernández, SilviaFolgueira Cobos, CintiaCastelao Taboada, CeciliaPena León, VerónicaGonzález Saenz, PatriciaVázquez Cobela, RocíoAguilera, Concepción M.Gil Campos, MercedesBueno Lozano, GloriaGil, ÁngelMoreno, Luis A.Ruiz Piñón, ManuelGarcía Palacios, MaríaCasanueva Freijo, FelipeDiéguez González, CarlosNogueiras Pozo, RubénLeis Trabazo, María RosauraSeoane Camino, Luisa María2020-11-302020-11-302019Barja-Fernández, S.; Folgueira, C.; Castelao, C.; Pena-León, V.; González-Saenz, P.; Vázquez-Cobela, R.; Aguilera, C.M.; Gil-Campos, M.; Bueno, G.; Gil, Á.; Moreno, L.A.; Ruiz-Piñon, M.; García-Palacios, M.; Casanueva, F.F.; Diéguez, C.; Nogueiras, R.; Leis, R.; Seoane, L.M. ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents. Nutrients 2019, 11, 1340http://hdl.handle.net/10347/23875Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3–17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5–18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profileeng© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/ANGPTL-4BMI lossChildhoodLipid profileObesityjournal article10.3390/nu110613402072-6643open access