Otero Casal, Ana MaríaParga Martínez, Ana2023-03-172023http://hdl.handle.net/10347/30338The present thesis investigates the potential of inhibiting bacterial cell-cell communication, quorum sensing (QS), to modulate oral biofilm formation. The thesis evaluates the effect of a quorum quenching (QQ) enzyme that degrades N-acylhomoserine lactones, the QS signals of gram-negative bacteria, on in vitro polymicrobial oral biofilms. The potential interactions between AHLs and a gram-positive representative, Enterococcus faecalis, were also investigated. The results presented here support the translation of QQ strategies to in vivo trials for the modulation of oral biofilms. In addition, a more intricate role of AHLs on oral biofilm formation and interactions with gram-positive bacteria is proposed.engAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/quorum sensingquorum quenchingAHLsoral microbiologyoral biofilmoral diseasesMaterias::Investigación::24 Ciencias de la vida::2414 Microbiología::241408 Procesos microbianosMaterias::Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320103 Microbiología clínicaMaterias::Investigación::24 Ciencias de la vida::2415 Biología molecular::241501 Biología molecular de microorganismosdoctoral thesisopen access