Schulz, FabianGarcía Melo, FátimaKaisser, KatharinaPérez Meirás, María DoloresGuitián Rivera, EnriqueGross, LeoPeña Gil, Diego2020-04-132020-04-132019F. Schulz, F. García, K. Kaiser, D. Pérez, E. Guitián, L. Gross, D. Peña, Angew. Chem. Int. Ed. 2019, 58, 90381433-7851http://hdl.handle.net/10347/21332A route to generate cyclacenes by on-surface synthesis is explored. We started by synthesizing two tetraepoxycyclacenes by sequences of Diels–Alder cycloadditions. Subsequently, these molecules were deposited onto Cu(111) and scanning-tunneling-microscopy(STM)-based atom manipulation was employed to dissociate the oxygen atoms. Atomic force microscopy (AFM) with CO-functionalized tips enabled the detailed characterization of the reaction products and revealed that, at most, two oxygens per molecule could be removed. Importantly, our experimental results suggest that the generation of cyclacenes by the described route might be possible for larger epoxycyclaceneseng© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are madehttp://creativecommons.org/licenses/by-nc-nd/4.0/Atomic force microscopyArynesCarbon nanobeltsCyclacenesCycloadditionsScanning tunneling microscopyjournal article10.1002/anie.2019027841521-3773open access