Varela-López, BenxamínRivas Fernández, Miguel ÁngelZurrón Ocio, MontserratLindín Novo, MónicaDíaz Fernández, FernandoGaldo Álvarez, Santiago2025-05-232025-05-232025-03-31International Psychogeriatrics Available online 31 March 2025, 1000671041-6102https://hdl.handle.net/10347/41794Objectives The aim of this study was to determine whether individuals with Subjective Cognitive Decline (SCD), particularly those with a neurostructural marker of risk for AD (SCD+), exhibit differences in the functional connectivity of the Default-Mode Network (DMN) relative to controls, as this network is known to be altered in the AD continuum. Design Cross-sectional study. Setting Galicia, Northwest Spain. Participants The sample compromised 133 participants: 69 controls, 51 SCD and 13 SCD+. Measurements Seed-to-voxel analysis was conducted using four DMN ROIs. Dynamic independent component analysis of the DMN was also performed. Results The SCD and SCD+ groups exhibited DMN hyperconnectivity, which was more extensive in the SCD+ group. Increased anti-correlations between DMN and task-positive parietal regions were related to poorer executive scores in SCD+ and a tendency for higher DMN recurrence in SCD+. Conclusions Hippocampal atrophy as a SCD+ biomarker is associated with extensive DMN hyperconnectivity and increased anti-correlations between DMN and task-positive network regions.eng© 2025 The Author(s). Published by Elsevier Inc. on behalf of International Psychogeriatric Association. This is an open access article under the CC BY- NC-ND license. Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Default-mode networkHippocampusSubjective cognitive declineTask-positive networksResting-stateFMRIAlzheimer’s DiseaseDementiajournal article10.1016/j.inpsyc.2025.100067open access