Pérez Camiña, JesúsPazos Randulfe, YolandaCalviño Lodeiro, Andrea2026-04-202026-04-202026https://hdl.handle.net/10347/46789Cancer-associated cachexia is a multifactorial syndrome that is characterised by the progressive loss of skeletal muscle and fat mass. We established two different cancer cachexia mouse models to evaluate the therapeutic potential of extracellular myogenic regulatory signals (EMRS). EMRS treatment improved the muscle function in both models. Mechanistically, EMRS reduced muscle atrophy by inhibiting the catabolic action of the ubiquitin-proteasome system, while also promoting myogenesis and homeostasis of the neuromuscular junctions. Thus, EMRS constitute a promising new approach for treating cancer-associated cachexia.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/cancer-associated cachexiaskeletal muscleEMRS240113 Fisiología animal241110 Fisiología del músculodoctoral thesisembargoed access