Suárez-Oubiña, CristianHerbello Hermelo, PalomaBermejo Barrera, PilarMoreda Piñeiro, Antonio2022-04-042022-04-042022Spectrochimica Acta Part B: Atomic Spectroscopy 187 (2022) 106330. https://doi.org/10.1016/j.sab.2021.106330http://hdl.handle.net/10347/27893Analytical methods based on dynamic-reaction cell (DRC) technology using ammonia as a reaction gas have been developed for the determination of ultra-trace Ti, Zn, Cu and Ag by inductively coupled plasma mass spectrometry (ICP-MS). Challenging spectral interferences from complex matrices were demonstrated to be overcome by DRC, and several DRC approaches (on-mass and mass-shift) using ammonium (NH3) as a reaction gas were assessed and compared to the standard or “vented” mode analysis. Ammonium cluster ions were generated for Ti, Cu, Zn, and Ag (mass shift approach). The on-mass approach was also explored to take advantage of collisional focusing phenomena. In addition, DRC operating conditions were optimised by modifying NH3 gas flow rate and rejection parameter q (RPq). The optimised conditions were applied to show the usefulness of either on-mass or mass-shift approaches when removing Ca and P interferences. Finally, the sensitivity of all measurement modes was studied and excellent limits of detection (at few ng L−1 levels) were assessedeng© 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)http://creativecommons.org/licenses/by-nc-nd/4.0/Dynamic-reaction cellAmmonium reaction gasInductively coupled plasma mass spectrometryInterferencesOn-mass approachMass shift approachjournal article10.1016/j.sab.2021.1063300584-8547open access