Destito, PaoloSousa Castillo, AnaRodríguez Couceiro, JoséLópez García, FernandoCorrea Duarte, Miguel ÁngelMascareñas Cid, José Luis2019-03-212019-03-212019Destito, P., Sousa-Castillo, A., Couceiro, J., López, F., Correa-Duarte, M., & Mascareñas, J. (2019). Hollow nanoreactors for Pd-catalyzed Suzuki–Miyaura coupling and O-propargyl cleavage reactions in bio-relevant aqueous media. Chemical Science, 10(9), 2598-2603. doi: 10.1039/c8sc04390f2041-6539http://hdl.handle.net/10347/18462We describe the fabrication of hollow microspheres consisting of mesoporous silica nanoshells decorated with an inner layer of palladium nanoparticles and their use as Pd-nanoreactors in aqueous media. These palladium-equipped capsules can be used to promote the uncaging of propargyl-protected phenols, as well as Suzuki–Miyaura cross-coupling, in water and at physiologically compatible temperatures. Importantly, the depropargylation reaction can be accomplished in a bioorthogonal manner in the presence of relatively high concentrations of biomolecular components and even in the presence of mammalian cellseng© The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution 3.0 Unported Licencehttps://creativecommons.org/licenses/by/3.0/journal article10.1039/c8sc04390fopen access