Rivas Rey, JoséBañobre López, ManuelSalonen, LauraGuldris Pensado, Noelia2017-04-182017-04-182017http://hdl.handle.net/10347/15296Nanomedicine is a new field employing nanotechnology tools for biomedical applications. Nanomaterials feature sizes between 1 and 100 hundred nanometers, and therefore they fill the gap between single molecules and bulk materials. They open the possibility to access biological processes on the same size scale. Nanoparticles have shown great potential to achieve the goal of personalized medicine due to the possibilities to modify their surface with proteins, targeting molecules, or imaging probes. Particularly, iron oxide nanoparticles show promising properties for successful application in biomedicine due to their low-cost production, high biocompatibility, and great magnetic response. Strategies for the functionalization of inorganic cores have been developed over the past years, and efforts have been devoted to engineering nanoparticles with multifunctional ligands on the surface to enable active tumor targeting, detection over different imaging modalities, and stimulus-driven cargo release. During this Ph.D. thesis, three main aspects of iron oxide nanoparticles have been evaluated. First, the stability of nanoparticles has been addressed in biological fluids. Second, the uptake of nanoparticles by stem cells for cell tracking applications was studied with nanoparticles of different sizes and bearing different organic coatings. Third, new possibilities of chemical functionalization of naked iron oxide nanoparticles by orthogonal processes have been explored, in order to achieve high yields, simplicity and high reproducibility.engEsta obra atópase baixo unha licenza internacional Creative Commons BY-NC-ND 4.0. Calquera forma de reprodución, distribución, comunicación pública ou transformación desta obra non incluída na licenza Creative Commons BY-NC-ND 4.0 só pode ser realizada coa autorización expresa dos titulares, salvo excepción prevista pola lei. Pode acceder Vde. ao texto completo da licenza nesta ligazón: https://creativecommons.org/licenses/by-nc-nd/4.0/deed.glhttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.glnanoparticlesiron oxideclick chemistryMRIMaterias::Investigación::22 Física::2210 Química física::221028-1 Preparación y caracterización de materiales inorgánicosMaterias::Investigación::33 Ciencias tecnológicas::3303 ingeniería y tecnología químicas::330305 Síntesis químicadoctoral thesisopen access