RT Dissertation/Thesis
T1 Simulation of Clinical PET Studies for the Assessment of Quantification Methods
A1 Silva Rodríguez, Jesús
K1 Positron Emission Tomography
K1 PET quantification
K1 Nuclear Medicine
K1 Medical Imaging
AB On this PhD thesis we developed amethodology for evaluating the robustness of SUV measurements based on MC simulations andthe generation of novel databases of simulated studies based on digital anthropomorphicphantoms. This methodology has been applied to different problems related to quantification thatwere not previously addressed. Two methods for estimating the extravasated dose were proposedandvalidated in different scenarios using MC simulations. We studied the impact of noise and lowcounting in the accuracy and repeatability of three commonly used SUV metrics (SUVmax,SUVmean and SUV50). The same model was used to study the effect of physiological muscularuptake variations on the quantification of FDG-PET studies. Finally, our MC models were applied tosimulate 18F-fluorocholine (FCH) studies. The aim was to study the effect of spill-in counts fromneighbouring regions on the quantification of small regions close to high activity extended sources.
YR 2017
FD 2017
LK http://hdl.handle.net/10347/15690
UL http://hdl.handle.net/10347/15690
LA eng
DS Minerva
RD 22 abr 2026