RT Dissertation/Thesis
T1 Nanotechnology for the modulation of the immune response in HIV and cancer
A1 Gómez Dacoba, Tamara
K1 HIV vaccine
K1 Cancer immunotherapy
K1 Nanotechnology
AB Nanotechnologies with the ability to modulate the immune system can be exploited to develop new advanced therapies. The first part of this thesis describes a potential HIV vaccine candidate consisting of nanoparticles loaded with up to three peptide antigens. Based on the good responses in terms of protection against viral infection in macaques, the quality-by-design and scaling-up production of this vaccine candidate was performed. Finally, in the context of cancer, a potential immunotherapy with the capacity to polarize tumor-associated macrophages towards anti-tumoral phenotypes was developed.
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23326
UL http://hdl.handle.net/10347/23326
LA eng
DS Minerva
RD 22 abr 2026