RT Journal Article
T1 Red Cell Distribution Width as a Predictive Factor of Celiac Disease in Middle and Late Adulthood and Its Potential Utility as Celiac Disease Screening Criterion
A1 Cabo del Riego, Julia María
A1 Núñez Iglesias, María Jesús
A1 Paz Carreira, José
A1 Blanco Hortas, Andrés
A1 Álvarez Fernández, Tamara
A1 Novío Mallón, Silvia
A1 Zaera, Sofía
A1 Freire-Garabal Núñez, Manuel
K1 Red blood width
K1 Celiac disease
K1 Onset
K1 Diagnosis
K1 Adult
K1 Elderly
AB Red cell distribution width (RDW) could be of interest by its potential use in the assessment of celiac disorder (CD). The main objective of this study was to evaluate the case positive rate of CD and the utility of red cell distribution width (RDW) in the CD diagnosis. This prospective study included 9.066 middle adult (≥45 years old) and elderly patients (≥60 years old) from 2012 to 2021. CD diagnosis was performed by CD antibody tests (serology and Human Leucocyte Antigen genotype (HLA)) and biopsy. Gastrointestinal and extra-intestinal manifestations as well as hematological and biochemical parameters were analyzed. CD diagnoses were confirmed in 101 patients (median (IQR) age = 62 (52.3–73); 68.32% women) by serologic tests (100%) and intestinal biopsy (88.12%), showing mainly marked or complete atrophy (76.24%, MARSH 3a–c). Anemia was the most commonly presenting extra-intestinal manifestation (28.57%). Among 8975 individuals without CD, 168 age and sex matched were included. By comparison of CD and no CD individuals, we observed that high >14.3% RDW was exhibited by 58.40% and 35.2% individuals with CD and without CD, respectively. Furthermore, high RDW is associated with CD and grade III atrophy. We suggest that RDW could be used as a CD screening criterion.
PB MDPI
SN 1660-4601
YR 2022
FD 2022-12-21
LK https://hdl.handle.net/10347/43340
UL https://hdl.handle.net/10347/43340
LA eng
NO Cabo del Riego, J.M.; Núñez-Iglesias, M.J.; Paz Carreira, J.; Blanco Hortas, A.; Álvarez Fernández, T.; Novío Mallón, S.; Zaera, S.; Freire-Garabal Núñez, M. Red Cell Distribution Width as a Predictive Factor of Celiac Disease in Middle and Late Adulthood and Its Potential Utility as Celiac Disease Screening Criterion. Int. J. Environ. Res. Public Health 2023, 20, 66. https://doi.org/10.3390/ ijerph20010066
DS Minerva
RD 28 abr 2026