RT Journal Article
T1 Development of Superparamagnetic Nanoparticles Coated with Polyacrylic Acid and Aluminum Hydroxide as an Efficient Contrast Agent for Multimodal Imaging
A1 González Gómez, Manuel Antonio
A1 Belderbos, Sarah
A1 Yáñez Vilar, Susana
A1 Piñeiro Redondo, Yolanda
A1 Cleeren, Frederik
A1 Bormans, Guy
A1 Deroose, Christophe M.
A1 Gsell, Willy
A1 Himmelreich, Uwe
A1 Rivas Rey, José
K1 Magnetite (Fe3O4)
K1 Superparamagnetic nanoparticles (SPMNPs)
K1 Aluminum hydroxide (Al(OH)3)
K1 Multimodal imaging
K1 MRI
K1 PET
K1 Biomedical applications
AB Early diagnosis of disease and follow-up of therapy is of vital importance for appropriatepatient management since it allows rapid treatment, thereby reducing mortality and improvinghealth and quality of life with lower expenditure for health care systems. New approaches includenanomedicine-based diagnosis combined with therapy. Nanoparticles (NPs), as contrast agentsfor in vivo diagnosis, have the advantage of combining several imaging agents that are visibleusing different modalities, thereby achieving high spatial resolution, high sensitivity, high specificity,morphological, and functional information. In this work, we present the development of aluminumhydroxide nanostructures embedded with polyacrylic acid (PAA) coated iron oxide superparamagneticnanoparticles, Fe3O4@Al(OH)3, synthesized by a two-step co-precipitation and forced hydrolysismethod, their physicochemical characterization and first biomedical studies as dual magnetic resonanceimaging (MRI)/positron emission tomography (PET) contrast agents for cell imaging. The so-preparedNPs are size-controlled, with diameters below 250 nm, completely and homogeneously coated with anAl(OH)3 phase over the magnetite cores, superparamagnetic with high saturation magnetization value(Ms = 63 emu/g-Fe3O4), and porous at the surface with a chemical affinity for fluoride ion adsorption.The suitability as MRI and PET contrast agents was tested showing high transversal relaxivity (r2)(83.6 mM−1s−1) and rapid uptake of 18F-labeled fluoride ions as a PET tracer. The loading stabilitywith 18F-fluoride was tested in longitudinal experiments using water, buffer, and cell culture media.Even though the stability of the 18F-label varied, it remained stable under all conditions. A first in vivoexperiment indicates the suitability of Fe3O4@Al(OH)3 nanoparticles as a dual contrast agent forsensitive short-term (PET) and high-resolution long-term imaging (MRI).
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21342
UL http://hdl.handle.net/10347/21342
LA eng
NO González-Gómez, M.A.; Belderbos, S.; Yañez-Vilar, S.; Piñeiro, Y.; Cleeren, F.; Bormans, G.; Deroose, C.M.; Gsell, W.; Himmelreich, U.; Rivas, J. Development of Superparamagnetic Nanoparticles Coated with Polyacrylic Acid and Aluminum Hydroxide as an Efficient Contrast Agent for Multimodal Imaging. Nanomaterials 2019, 9, 1626
NO This work was supported by the European Commission under the PANA project, Call H2020-NMP2015-two-stage, Grant 686009, and partially supported by the Consellería de Educación Program for theDevelopment of Strategic Grouping in Materials—AEMAT at the University of Santiago de Compostela underGrant No. ED431E2018/08, Xunta de Galicia, and the Flemish Agency for Innovation by Science and Technology(IWT grant agreement n◦ 140061, SBO ‘NanoCoMIT’). Furthermore, we acknowledge infrastructure funding forthe preclinical PET/MRI scanner from ‘Stichting tegen Kanker’ (STK 2015-145) and from the Hercules Stichting(AKUL/13/29). Frederik Cleeren is a Postdoctoral Fellow of The Research Foundation—Flanders (FWO; 12R3119N)
DS Minerva
RD 27 abr 2026