RT Journal Article
T1 Distinguishing between heating power and hyperthermic cell-treatment efficacy in magnetic fluid hyperthermia
A1 Munoz-Menendez, Cristina
A1 Conde Leborán, Iván
A1 Serantes Abalo, David
A1 Chantrell, Roy W.
A1 Chubykalo-Fesenko, Oksana
A1 Baldomir Fernández, Daniel
K1 Magnetic hyperthermia
K1 Magnetic nanoparticles
K1 Local heating
AB In the magnetic fluid hyperthermia (MFH) research field, it is usually assumed that achieving a uniform temperature enhancement (ΔT) of the entire tumour is a key-point for treatment. However, various experimental works reported successful cell apoptosis via MFH without a noticeable ΔT of the system. A possible explanation of the success of these negligible-ΔT experiments is that a local ΔT restricted to the particle nanoenvironment (i.e. with no significant effect on the global temperature T) could be enough to trigger cell death. Shedding light on such a possibility requires accurate knowledge of heat dissipation at the local level in relation to the usually investigated global (average) one. Since size polydispersity is inherent to all synthesis techniques and the heat released is proportional to the particle size, heat dissipation spots with different performances – and thus different effects on the cells – will likely exist in every sample. In this work we aim for a double objective: (1) to emphasize the necessity to distinguish between the total dissipated heat and hyperthermia effectiveness, and (2) to suggest a theoretical approach on how to select, for a given size polydispersity, a more adequate average size so that most of the particles dissipate within a desired heating power range. The results are reported in terms of Fe3O4 nanoparticles as a representative example
PB Royal Society of Chemistry
YR 2016
FD 2016-10-07
LK http://hdl.handle.net/10347/16802
UL http://hdl.handle.net/10347/16802
LA eng
NO Munoz-Menendez, C., Conde-Leboran, I., Serantes, D., Chantrell, R., Chubykalo-Fesenko, O., & Baldomir, D. (2016). Distinguishing between heating power and hyperthermic cell-treatment efficacy in magnetic fluid hyperthermia. Soft Matter, 12(43), 8815-8818. doi: 10.1039/c6sm01910b
NO This is the accepted version of the manuscript having the following citation: Munoz-Menendez, C., Conde-Leboran, I., Serantes, D., Chantrell, R., Chubykalo-Fesenko, O., & Baldomir, D. (2016). Distinguishing between heating power and hyperthermic cell-treatment efficacy in magnetic fluid hyperthermia. Soft Matter, 12(43), 8815-8818. doi: 10.1039/c6sm01910b
NO The authors thank the Centro de Supercomputación de Galicia (CESGA) for the computational facilities. This work was co-financed by the Spanish MINECO (Project MAT201347078-C2-2-P) and Xunta de Galicia, Spain (Project GRC 2014/ 013 and financial support of D. S. under Plan I2C)
DS Minerva
RD 24 abr 2026