RT Journal Article
T1 Clinical translation of injectable hydrogels: from bioactive polymers to long-acting drug delivery systems
A1 Carballo Pedrares, Natalia
A1 Martín Giménez, Virna Margarita
A1 Alonso Fernández, María José
K1 Biomaterials
K1 Injectable hydrogels
K1 Drug delivery systems
K1 Clinical translation
K1 Personalized medicine
AB Injectable hydrogels (IHs) have emerged as versatile biomaterials that enable localized therapy through minimally invasive delivery. Their in situ sol–gel transition supports sustained and targeted release of therapeutics, enhancing patient comfort and reducing dosing frequency. However, clinical translation remains limited due to challenges in achieving controlled degradation, ensuring long-term biocompatibility, scaling production, and meeting regulatory standards. Despite these hurdles, several IH-based formulations are progressing through clinical trials or have reached the market, underscoring their therapeutic potential. This review examines the major translational barriers and highlights recent advances that are accelerating the adoption of IHs in precision and personalized medicine.
PB Springer
SN 2190-393X
YR 2026
FD 2026-01-22
LK https://hdl.handle.net/10347/46776
UL https://hdl.handle.net/10347/46776
LA eng
NO Carballo Pedrares, N., Giménez Martín, V.M., & Alonso, M.J. (2026). Clinical translation of injectable hydrogels: from bioactive polymers to long-acting drug delivery systems. Drug Delivery And Translational Research. https://doi.org/10.1007/s13346-025-02033-1
NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.
NO This work has received financial support from: Competitive Reference Groups 2025, Consellería de Educación, Ciencia, Universidades e Formación Profesional, Ref. ED431C 2025/01. Xunta de Galicia (Centro singular de investigación de Galicia accreditation ED431G/2023/02) and the European Union (European Regional Development Fund—ERDF).
DS Minerva
RD 18 abr 2026