RT Journal Article
T1 Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes
A1 Sánchez López, Mateo Isidro
A1 Vázquez Vázquez, Olalla
A1 Martínez Costas, José Manuel
A1 Vázquez Sentís, Marco Eugenio
A1 Mascareñas Cid, José Luis
AB Bisbenzamidines are an important family of minor groove DNA-binding agents. We present a one-step synthesis of aromatic aza-bisbenzamidines that allows straightforward and versatile access to a large number of these molecules. One of them, the azide-aza-bisbenzamidine 13, can be readily modified via click-chemistry with a variety of functionalities that can, therefore, be delivered to the vicinity of an A/T-rich DNA minor groove. This strategy, therefore, provides a simple means for triggering site selective, DNA-promoted biochemical and physicochemical processes
PB Royal Society of Chemistry
YR 2012
FD 2012
LK http://hdl.handle.net/10347/18489
UL http://hdl.handle.net/10347/18489
LA eng
NO Sánchez, M., Vázquez, O., Martínez-Costas, J., Vázquez, M., & Mascareñas, J. (2012). Straightforward access to bisbenzamidine DNA binders and their use as versatile adaptors for DNA-promoted processes. Chem. Sci., 3, 2383-2387. doi: 10.1039/c2sc00027j
DS Minerva
RD 23 abr 2026