RT Journal Article
T1 Plasma miR-486-5p Expression Is Upregulated in Atrial Fibrillation Patients with Broader Low-Voltage Areas
A1 Cebro Márquez, María
A1 Rodríguez Mañero, Moisés
A1 Serrano Cruz, Valentina
A1 Vilar Sánchez, Marta
A1 González Melchor, Laila
A1 García Seara, Javier
A1 Martínez Sande, José Luis
A1 Aragón Herrera, Alana
A1 Martínez Monzonís, María Amparo
A1 González Juanatey, José Ramón
A1 Lage Fernández, Ricardo
A1 Moscoso Galán, Isabel
K1 Atrial fibrillation
K1 microRNAs
K1 Low-voltage areas
K1 Biomarkers
K1 miR-486-5p
AB Atrial fibrillation (AF) is the most common arrhythmia worldwide, affecting 1% of the population over 60 years old. The incidence and prevalence of AF are increasing globally, representing a relevant health problem, suggesting that more advanced strategies for predicting risk stage are highly needed. miRNAs mediate several processes involved in AF. Our aim was to identify miRNAs with a prognostic value as biomarkers in patients referred for AF ablation and its association with LVA extent, based on low-voltage area (LVA) maps. In this study, we recruited 44 AF patients referred for catheter ablation. We measured the expression of 84 miRNAs in plasma from peripheral blood in 3 different groups based on LVA extent. Expression analysis showed that miR-486-5p was significantly increased in patients with broader LVA (4-fold, p = 0.0002; 5-fold, p = 0.0001). Receiver operating characteristic curve analysis showed that miR-486-5p expression could predict atrium LVA (AUC, 0.8958; p = 0.0015). Also, miR-486-5p plasma levels were associated with AF-type (AUC, 0.7137; p = 0.0453). In addition, miR-486-5p expression was positively correlated with LVA percentage, left atrial (LA) area, and LA volume (r = 0.322, p = 0.037; r = 0.372, p = 0.015; r = 0.319, p = 0.045, respectively). These findings suggest that miR-486-5p expression might have prognostic significance in LVA extent in patients with AF
PB MDPI
YR 2023
FD 2023
LK http://hdl.handle.net/10347/32199
UL http://hdl.handle.net/10347/32199
LA eng
NO Cebro-Márquez, M.; Rodríguez-Mañero, M.; Serrano-Cruz, V.; Vilar-Sánchez, M.E.; González-Melchor, L.; García-Seara, J.; Martínez-Sande, J.L.; Aragón-Herrera, A.; Martínez-Monzonís, M.A.; González-Juanatey, J.R.; et al. Plasma miR-486-5p Expression Is Upregulated in Atrial Fibrillation Patients with Broader Low-Voltage Areas. Int. J. Mol. Sci. 2023, 24, 15248. https://doi.org/10.3390/ijms242015248
NO This research was funded by Xunta de Galicia: Programa de Consolidación de Unidades de Investigación Competitivas do SUG (GRC 2019/02), the Centro Singular de Investigación de Galicia acreditación 2019–2022 (ED431G 2019/02), the European Union European Regional Development Fund (ERDF), and National Institute of Health Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (ISCIII) Madrid, Spain (PI18/00821, CIBERCV CB16/11/00226 and FAISCA Intramural Project 2019)
DS Minerva
RD 28 abr 2026