RT Dissertation/Thesis
T1 Gold-mediated reactions and photocatalytic transformations in biological environments
A1 D'Avino, Cinzia
K1 bioorthogonal
K1 metal
K1 gold
K1 photocatalysis
K1 cells
AB This thesis explores the development of gold catalyzed and photocatalytic bioorthogonal reactions under physiologically relevant conditions. Gold catalysis enables mild hydrolysis of ynamides to amides and cascade reactions from anilines to carbazoles, demonstrating good performance in aqueous and biologically relevant media. Photocatalytic transformations allow the formation of indoles from aryl azides with excellent biocompatibility, including cell selective imaging through peptide photocatalyst conjugates. Overall, these results highlight strategies for the in situ generation of bioactive scaffolds in living systems, expanding the toolbox for bioorthogonal chemistry.
YR 2026
FD 2026
LK https://hdl.handle.net/10347/45915
UL https://hdl.handle.net/10347/45915
LA eng
DS Minerva
RD 21 abr 2026