RT Journal Article
T1 Design of polymeric nanocapsules to improve their lympho-targeting capacity
A1 Crecente Campo, José
A1 Virgilio, Tommaso
A1 Morone, Diego
A1 Calviño-Sampedro, Cristina
A1 Fernández-Mariño, Iago
A1 Olivera, Ana
A1 Varela Calviño, Rubén
A1 González, Santiago F.
A1 Alonso Fernández, María José
K1 Inulin
K1 Chitosan
K1 Nanocapsules
K1 Particle size
K1 Targeting
K1 Dendritic cells
K1 Lymph nodes
K1 2-photon microscopy
AB Aim: To design lympho-targeted nanocarriers for enhancing the activity of associated drugs/antigens whose target is within the lymphatic system. Materials & Methods: inulin-based NCs, negatively charged, and positively charged chitosan NCs were prepared by the solvent displacement techniques. The NCs were produced in two sizes: small (70 nm) and medium (170 – 250 nm). Results: In vitro results indicated that the small NCs interacted more with dendritic cells. The study of the NCs biodistribution in mice, using 3D reconstruction of the popliteal lymph node, showed the highest accumulation for small inulin NCs. These NCs exhibited the greatest interaction with all the subsets of resident immune cells. Conclusion: small inulin NCs confirmed their foreseen lympho-targeting properties.
PB Taylor and Francis
SN 1743-5889
YR 2019
FD 2019-11-07
LK https://hdl.handle.net/10347/39028
UL https://hdl.handle.net/10347/39028
LA eng
NO Crecente-Campo, J., Virgilio, T., Morone, D., Calviño-Sampedro, C., Fernández-Mariño, I., Olivera, A., … Alonso, M. J. (2019). Design of Polymeric Nanocapsules to Improve Their lympho-targeting Capacity. Nanomedicine, 14(23), 3013–3033. https://doi.org/10.2217/nnm-2019-0206
NO This is an Accepted Manuscript of an article published by Taylor & Francis in Nanomedicine on 7 Nov 2019, available at: https://doi.org/10.2217/nnm-2019-0206
DS Minerva
RD 7 jun 2026