RT Journal Article
T1 Pegvisomant-Induced Cholestatic Hepatitis in an Acromegalic Patient with UGT1A1∗ 28 Mutation
A1 Mallea-Gil, Maria Susana
A1 Bernabeu, Ignacio
A1 Spiraquis, Adriana
A1 Avangina, Alejandra
A1 Loidi, Lourdes
A1 Ballarino, Carolina
AB Pegvisomant (PEGv) is a growth hormone receptor antagonist approved for the treatment of acromegaly; one of its documented adverse effects is reversible elevation of hepatic enzymes. We report a 39-year-old male acromegalic patient with a pituitary macroadenoma who underwent transsphenoidal surgery. The patient’s condition improved but GH and IGF-I levels did not normalize; as a consequence, we first administered dopamine agonists and then somatostatin receptor ligands (SRLs) with poor response. PEGv 15mg every other day was added to lanreotide 120mg monthly. The patient developed a severe hepatitis five months after starting the combination therapy. Elevated ferritin, iron, and transferrin saturation suggested probable hepatitis due to haemochromatosis. We performed a liver biopsy which showed an acute cholestatic hepatitis consistent with toxic etiology. A heterozygous genotype UGT1A1∗28 polymorphism associated with Gilbert’s syndrome was also found in this Argentine patient. The predominant clinical presentation resembled an acute cholestatic hepatitis associated with severe hemosiderosis, a different and new pattern of PEGv hepatotoxicity
PB Hindawi
SN 2090-6501
YR 2016
FD 2016
LK http://hdl.handle.net/10347/16081
UL http://hdl.handle.net/10347/16081
LA eng
NO Maria Susana Mallea-Gil, Ignacio Bernabeu, Adriana Spiraquis, Alejandra Avangina, Lourdes Loidi, and Carolina Ballarino, “Pegvisomant-Induced Cholestatic Hepatitis in an Acromegalic Patient with UGT1A128 Mutation,” Case Reports in Endocrinology, vol. 2016, Article ID 2087102, 5 pages, 2016. doi:10.1155/2016/2087102
DS Minerva
RD 23 abr 2026