RT Journal Article
T1 Testing drug release from medicated contact lenses: the missing link to predict in vivo performance
A1 Mota, Ana F. Pereira da
A1 Phan, Chau-Minh
A1 Concheiro Nine, Ángel Joaquín
A1 Jones, Lyndon
A1 Álvarez Lorenzo, Carmen
K1 Drug-eluting contact lens
K1 In vitro release tests
K1 In vivo release
K1 Release rate specifications
K1 Therapeutic response
K1 In vitro-in vivo correlations
AB Contact lenses (CLs) offer a wide variety of advantages as ocular drug-releasing platforms, but the feasibility of medicated CL development is constrained by numerous scientific, technological, and regulatory challenges. One main difficulty is the setting of release rate specifications for each drug, since at present there are no standardized in vitro release models that can appropriately predict the performance of drug-eluting CLs once placed onto the eye. CL-adapted release tests may provide knowledge on how the drug release pattern should perform in vivo to trigger and maintain the therapeutic effects for both anterior and posterior ocular tissues. Moreover, in vitro release tests are valuable tools for quality assessment during production and to investigate the effect of a change in composition or process variables. This review aims to shed light on biorelevant ways of evaluating in vitro drug release from CLs and the feasibility of establishing in vitro-in vivo correlations (IVIVC) to predict in vivo performance. First, general guidelines and Pharmacopeia release tests for topical ophthalmic formulations as well as in vitro release tests implemented for drug-CLs in the last two decades are analyzed. Then, development of an appropriate method to investigate IVIVC is attempted from the few papers simultaneously reporting in vitro release profiles and either in vivo release or therapeutic response. Finally, key points to be considered for in vitro testing drug release from a medicated CL are suggested to pave the way to the clinical arena
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/27634
UL http://hdl.handle.net/10347/27634
LA eng
NO Journal of Controlled Release 343 (2022) 672-702
NO This project is funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Actions grant agreement N° 813440 (ORBITAL–Ocular Research by Integrated Training And Learning). The work was also partially supported by MCIN [PID2020-113881RB-I00/AEI/10.13039/501100011033] Spain, Xunta de Galicia [ED431C 2020/17], and FEDER
DS Minerva
RD 22 abr 2026