RT Journal Article
T1 Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
A1 Rodríguez Pombo, Lucía
A1 Martínez Castro, Laura
A1 Xu, Xiaoyan
A1 Ong, Jun Jie
A1 Rial, Carlos
A1 García, Daniel Nieto
A1 González Santos, Alejandro
A1 Flores González, Julián Carlos
A1 Álvarez Lorenzo, Carmen
A1 Basit, Abdul W.
A1 Goyanes Goyanes, Álvaro
K1 Vat photopolymerization 3D printed medicines
K1 3D rotary printing
K1 Tomographic reconstruction
K1 3D printed drug products
K1 Printing pharmaceuticals and drug delivery systems
K1 Personalized formulations
AB 3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry.
PB Elsevier
SN 2590-1567
YR 2023
FD 2023-02-15
LK https://hdl.handle.net/10347/43319
UL https://hdl.handle.net/10347/43319
LA eng
NO International Journal of Pharmaceutics: X Volume 5, December 2023, 100166
NO The work was partially supported by MCIN [PID 2020-113881RB-I00/AEI/10.13039/501100011033], Spain, Xunta de Galicia [ED431C 2020/17], and FEDER. LRP acknowledges the predoctoral fellowship [FPU20/01245] provided by the Ministerio de Universidades [Formación de Profesorado Universitario (FPU 2020)].
DS Minerva
RD 28 abr 2026