RT Dissertation/Thesis
T1 Pharmaceutical compounding and drug repositioning from hospital pharmacy in situations of therapeutic gap
A1 Castro Balado, Ana
K1 Pharmaceutical compounding
K1 ocular cystinosis
K1 cysteamine
K1 SARS-CoV-2
K1 Inhaled ethanol
AB This doctoral thesis focuses on offering therapeutic alternatives throughpharmaceutical compounding and drug repositioning from the hospital pharmacy to cover therapeutic gaps. Anophthalmic compounded formulation of cysteamine in hyaluronic acid packaged in novel single-dose containerswas developed for the treatment of ocular cystinosis. On the other hand, an inhaled compounded formulation ofethanol was developed for the treatment of SARS-CoV-2 infection, and subsequently studied for efficacy and safetyin the phase II clinical trial ALCOVID-19. In both cases, appropriate galenic development and characterisation hasbeen performed in conjunction with preclinical pharmacokinetic studies prior to appropriate translation into clinicalpractice.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30750
UL http://hdl.handle.net/10347/30750
LA eng
DS Minerva
RD 22 abr 2026