RT Dissertation/Thesis
T1 Selective recognition of threeway DNA junctions with designed peptidomimetics
A1 Alcalde Ordóñez, Ana
K1 DNA structures
K1 drugs
K1 peptide ligands
K1 stereoselective synthesis of dinuclear Cu(II)
AB Non-canonical DNA structures, such as three-way DNAjunctions (3WJs), formed during DNA replication, have emergedas promising alternative DNA targets for the development ofnew drugs with attractive therapeutic properties. In this context,supramolecular helicates have shown high selectivity andbinding affinity for 3WJs, but their use in this field is hamperedby the lack of synthetic versatility and a general strategy to theirenantioselective synthesis. In this thesis, we describe thestereoselective self-assembly of helicates derived from peptideligands equipped with 2,2’-bipyridine coordinating residues, aswell as the implementation of a new strategy that relies on thecooperative 3WJ-binding mechanism of natural proteins, to yieldnew systems with selective 3WJs recognition properties.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30922
UL http://hdl.handle.net/10347/30922
LA eng
DS Minerva
RD 23 abr 2026