RT Journal Article T1 Current Trends and New Challenges in Marine Phycotoxins A1 Louzao Ojeda, María del Carmen A1 Vilariño del Río, Natalia A1 Vale González, María del Carmen A1 Costas, Celia A1 Cao Cancelas, Alejandro A1 Raposo García, Sandra A1 Rodríguez Vieytes, Mercedes A1 Botana López, Luis Miguel K1 Phycotoxin K1 Mechanism of action K1 Toxicity K1 Therapeutic application K1 Detection methods AB Marine phycotoxins are a multiplicity of bioactive compounds which are produced by microalgae and bioaccumulate in the marine food web. Phycotoxins affect the ecosystem, pose a threat to human health, and have important economic effects on aquaculture and tourism worldwide. However, human health and food safety have been the primary concerns when considering the impacts of phycotoxins. Phycotoxins toxicity information, often used to set regulatory limits for these toxins in shellfish, lacks traceability of toxicity values highlighting the need for predefined toxicological criteria. Toxicity data together with adequate detection methods for monitoring procedures are crucial to protect human health. However, despite technological advances, there are still methodological uncertainties and high demand for universal phycotoxin detectors. This review focuses on these topics, including uncertainties of climate change, providing an overview of the current information as well as future perspectives. PB MDPI YR 2022 FD 2022 LK https://hdl.handle.net/10347/38572 UL https://hdl.handle.net/10347/38572 LA eng NO Louzao, M.C.; Vilariño, N.; Vale, C.; Costas, C.; Cao, A.; Raposo-Garcia, S.; Vieytes, M.R.; Botana, L.M. Current Trends and New Challenges in Marine Phycotoxins. Mar. Drugs 2022, 20, 198. https://doi.org/10.3390/ md20030198 NO The research leading to these results has received funding from the following FEDER cofunded grants. From Conselleria de Cultura, Educacion e Ordenación Universitaria, Xunta de Galicia, GRC (ED431C 2021/01). From Ministerio de Ciencia e Innovación IISCIII/PI19/001248 and PID 2020-11262RB-C21. From European Union Interreg AlertoxNet EAPA-317-2016, Interreg Agritox EAPA-998-2018, and H2020 778069-EMERTOX. Celia Costas is supported by a fellowship from the Ministerio de Ciencia, Innovacion y Universidades grant FPU18/05681. DS Minerva RD 23 abr 2026