RT Journal Article
T1 Alcohol-related stimuli modulate functional connectivity during response inhibition in young binge drinkers
A1 Blanco Ramos, Javier
A1 Antón Toro, Luis Fernando
A1 Cadaveira, Fernando
A1 Doallo, Sonia
A1 Suárez Suárez, Samuel
A1 Rodríguez Holguín, Socorro
K1 Alcohol
K1 Binge drinking
K1 Event-related potentials
K1 Functional connectivity
K1 Inhibitory control
K1 Consumo intensivo de alcohol
K1 Potenciais evocados
K1 Conectividade funcional
K1 Beta band
K1 Theta band
K1 Banda theta
K1 Banda beta
K1 EEG
AB Binge drinking is a pattern of intermittent excessive alcohol consumption that is highly prevalent in young people. Neurocognitive dual-process models have described substance abuse and adolescence risk behaviours as the result of an imbalance between an overactivated affective-automatic system (related to motivational processing) and damaged and/or immature reflective system (related to cognitive control abilities). Previous studies have evaluated the reflective system of binge drinkers (BDs) through neutral response inhibition tasks and have reported anomalies in theta (4–8 Hz) and beta (12–30 Hz) bands. The present study aimed to investigate the influence of the motivational value of alcohol-related stimuli on brain functional networks devoted to response inhibition in young BDs. Sixty eight BDs and 78 control participants performed a beverage Go/NoGo task while undergoing electrophysiological recording. Whole cortical brain functional connectivity (FC) was evaluated during successful response inhibition trials (NoGo). BDs exhibited fast-beta and theta hyperconnectivity in regions related to cognitive control. These responses were modulated differently depending on the motivational content of the stimuli. The increased salience of alcohol-related stimuli may lead to overactivation of the affective-automatic system in BDs, and compensatory neural resources of the reflective system will thus be required during response inhibition. In BDs, inhibition of the response to alcohol stimuli may require higher theta FC to facilitate integration of information related to the task goal (withholding a response), while during inhibition of the response to no-alcoholic stimuli, higher fast-beta FC would allow to apply top-down inhibitory control of the information related to the prepotent response
PB Wiley
SN 1369-1600
YR 2022
FD 2022
LK http://hdl.handle.net/10347/27509
UL http://hdl.handle.net/10347/27509
LA eng
NO Blanco-Ramos, J; Antón-Toro, LF; Cadaveira, F; Doallo, S; Suárez-Suárez, S; Rodríguez Holguín, S. (2022). Alcohol-related stimuli modulate functional connectivity during response inhibition in young binge drinkers. Addiction Biology, 27, e13141. https://doi.org/10.1111/adb.13141
NO Funding for this research was provided by the Plan Nacional Sobre Drogas (PNSD 2015/034) and Ministerio de Economía, Industria y Competitividad together with European Regional Development Fund (PSI2015-70525-P), Ministerio de Ciencia e Innovación (PID2020-113487RB-I00) and Xunta de Galicia (ED431C 2917/06). JBR was supported by the FPU program (FPU2015-03591) of the Spanish Ministry of Education, Culture and Sports. SSS was supported by a predoctoral fellowship from the Spanish Ministerio de Economía y Competitividad (BES-2016-076298).
DS Minerva
RD 10 may 2026