RT Journal Article
T1 Molecular basis of the effect of MMP-9 on the prostate bone metastasis: A review
A1 Pego Pérez, Emilio Rubén
A1 Fernández Rodríguez, Isaac
A1 Pumar Cebreiro, José Manuel
K1 Metalloproteinases
K1 MMP-9
K1 Cancer
K1 Prostate
K1 Bone
K1 Therapeutic targets
AB Introduction and objectiveProstate cancer (PCa) is the second most common cancer in men especially after 50 years old. The metastasis of said cancer involves a rise for morbidity, metastasizing 90% of the occasions on bone. Metalloproteinases (MMPs) are involved in the process of bone formation and they are postulated to be involved in the process of metastasizing, in particular MMP-9. This work is justified taking into account the scientific interest of the subject and the quality of the literature sources used. PCa generates a high morbidity and mortality in men, especially due to the process of metastasis, resulting in effects to health and socioeconomic level.MethodsThis search was performed selecting articles published from 2003 to 2017. Items were selected and valued according to the Cochrane criteria (2011).Findings and conclusionsThe selected articles (17) demonstrate the involvement of MMP-9 as a modulator of bone metastatic lesions either of osteoblast, osteoclast or mixed origin as well as the recognition of the major mechanisms or molecules involved in the regulation of expression gene of MMP-9 and finally establishing the MMP-9 as a therapeutic target for possible future drug development. Finally, this study evidences MMP-9 as an essential factor for the activation of the chain of the different MMPs and consequently in the genesis and development of bone metastasis of PCa due to its influence on bone osteoblastic and osteoclastic activity.
PB Elsevier
SN 1078-1439
YR 2018
FD 2018-06
LK https://hdl.handle.net/10347/39675
UL https://hdl.handle.net/10347/39675
LA eng
NO Pego Pérez, E.R., Fernández Rodríguez, I. & Pumar Cebreiro, J.M. (2018). Molecular basis of the effect of MMP-9 on the prostate bone metastasis: A review. Urologic Oncology: Seminars and Original Investigations, 36(6), 272-282. doi: https://doi.org/10.1016/j.urolonc.2018.03.009
NO Xunta de Galicia-FSE
DS Minerva
RD 23 abr 2026