RT Journal Article
T1 p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells
A1 Varela Rey, Marta María
A1 Montiel-Duarte, Cristina
A1 Osés-Prieto, Juan Antonio
A1 López-Zabalza, María Jesús
A1 Jaffrèzou, J. P.
A1 Rojkind, Marcos
A1 Iraburu, María José
K1 p38 MAPK
K1 TNF-alpha
K1 TGF-beta
K1 Hepatic stellate cells
K1 A-SMase
K1 alpha1 (I) procollagen
AB The role of members of the mitogen-activated protein kinase (MAPK) family on tumor necrosis factor alpha (TNF-alpha)-mediated down-regulation of col1a1 gene was studied. TNF-alpha increased extracellular-regulated kinase and Jun-N-terminal kinase phosphorylation, but these effects were not related to its inhibitory effect on alpha1(I) procollagen (col1a1) mRNA levels. Phosphorylation of p38 MAPK was decreased in response to TNF-alpha, and the specific p38 MAPK inhibitor SB203580 mimicked the effect of TNF-alpha on col1a1 mRNA levels. Transforming growth factor beta (TGF-beta) increased p38 MAPK phosphorylation and SB203580 prevented the induction of col1a1 mRNA levels by TGF-beta. These results suggest that p38 MAPK plays an important role in regulating the expression of col1a1 in hepatic stellate cells in response to cytokines.
PB Wiley / Federation of European Biochemical Societies
SN 1873-3468
YR 2002
FD 2002-09-25
LK https://hdl.handle.net/10347/39359
UL https://hdl.handle.net/10347/39359
LA eng
NO Varela-Rey, Montiel-Duarte, Osés-Prieto, López-Zabalza, Jaffrèzou, Rojkind, & Iraburu. (2002). p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells. FEBS Letters, 528(1-3), 133-138. https://doi.org/10.1016/S0014-5793(02)03276-3
NO In this report our results indicate that p38 MAPK is a keymediator of the anti-fibrogenic efect of TNF-alpha and the profibrogenic efect of TBF-beta in HSC.This is the peer reviewed version of the following article: Varela-Rey, Montiel-Duarte, Osés-Prieto, López-Zabalza, Jaffrèzou, Rojkind, & Iraburu. (2002). p38 MAPK mediates the regulation of α1(I) procollagen mRNA levels by TNF-α and TGF-β in a cell line of rat hepatic stellate cells. FEBS Letters, 528(1-3), 133-138, which has been published in final form at https://doi.org/10.1016/S0014-5793(02)03276-3. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
NO Fondo de Investigaciones Sanitarias (FIS) Grant 00/0143 and NIH Grant AA 10541
DS Minerva
RD 24 abr 2026