RT Journal Article
T1 Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study
A1 McCabe, Paul S.
A1 Pye, Stephen R.
A1 Mc Beth, John
A1 Lee, David M.
A1 Tajar, Abdelouahid
A1 Bartfai, Gyorgy
A1 Boonen, Steven
A1 Bouillon, Roger
A1 Casanueva Freijo, Felipe
A1 Finn, Joseph D.
A1 Forti, Gianni
A1 Giwercman, Aleksander
A1 Huhtaniemi, Ilpo T.
A1 Kula, Krzysztof
A1 Pendleton, Neil
A1 Punab, Margus
A1 Vanderschueren, Dirk
A1 Wu, Frederick C.
A1 O’Neill, Terence W.
A1 EMAS Study Group, 
K1 Chronic Widespread pain
K1 Chronic pain
K1 Vitamin D
K1 Epidemiology
K1 Obesity
K1 Depression
AB BackgroundThe association between low levels of vitamin D and the occurrence of chronic widespread pain (CWP) remains unclear. The aim of our analysis was to determine the relationship between low vitamin D levels and the risk of developing CWP in a population sample of middle age and elderly men.MethodsThree thousand three hundred sixty nine men aged 40–79 were recruited from 8 European centres for a longitudinal study of male ageing, the European Male Ageing Study. At baseline participants underwent assessment of lifestyle, health factors, physical characteristics and gave a fasting blood sample. The occurrence of pain was assessed at baseline and follow up (a mean of 4.3 years later) by shading painful sites on a body manikin. The presence of CWP was determined using the ACR criteria for fibromyalgia. Serum 25-hydroxyvitamin D (25-(OH) D) was assessed by radioimmunoassay. Logistic regression was used to determine the relationship between baseline vitamin D levels and the new occurrence of CWP.ResultsTwo thousand three hundred thirteen men, mean age 58.8 years (SD = 10.6), had complete pain and vitamin data available and contributed to this analysis. 151 (6.5 %) developed new CWP at follow up and 577 (24.9 %) were pain free at both time points, the comparator group. After adjustment for age and centre, physical performance and number of comorbidities, compared to those in upper quintile of 25-(OH) D ( ≥36.3 ng/mL), those in the lowest quintile (<15.6 ng/mL) were more likely to develop CWP (Odds Ratio [OR] = 1.93; 95 % CI = 1.0-3.6). Further adjustment for BMI (OR = 1.67; 95 % CI = 0.93-3.02) or depression (OR = 1.77; 95 % CI = 0.98-3.21), however rendered the association non-significant.ConclusionsLow vitamin D is linked with the new occurrence of CWP, although this may be explained by underlying adverse health factors, particularly obesity and depression.
PB Springer
YR 2016
FD 2016
LK http://hdl.handle.net/10347/22927
UL http://hdl.handle.net/10347/22927
LA eng
NO McCabe, P.S., Pye, S.R., Beth, J.M. et al. Low vitamin D and the risk of developing chronic widespread pain: results from the European male ageing study. BMC Musculoskelet Disord 17, 32 (2016). https://doi.org/10.1186/s12891-016-0881-6
NO The study was supported by the Commission of the European Communities Fifth Framework Program: ‘Quality of Life and Management of Living Resources’ [grant QLK6-CT-2001-00258]. Support was also provided by Arthritis Research UK [Grant 20380] and the National Institute of Health Research (NIHR) Manchester Musculoskeletal Biomedical Research Unit. PSM is an NIHR supported academic clinical fellow
DS Minerva
RD 24 abr 2026