RT Book,_Section
T1 The Reactions of Mitomycin C with Dithiols II. Formation of Dithiol Cross-Links
A1 Paz Castañal, Manuel María
AB We report that the clinically used antitumor drug mitomycin C reacts with excess dithiols to give dithiol cross-links as major products. Mechanistic studies reveal that three dithiol molecules participate at different stages of the reaction: in the reductive activation of mitomyicin C, in an alkylation at C1, and in an additional reduction that activates C10 for the second-arm alkylation by the dithiol. We hypothesize that the reactions reported here indicate that mitomycin C could act as a mechanism-based inhibitor of enzymes containing a dithiol active site
PB MDPI
SN 3-906980-24-3
YR 2010
FD 2010
LK http://hdl.handle.net/10347/26883
UL http://hdl.handle.net/10347/26883
LA eng
NO Proceedings of the 14th International Electronic Conference on Synthetic Organic Chemistry, 1–30 November 2010, MDPI: Basel, Switzerland, doi:10.3390/ecsoc-14-00483
NO The 14th International Electronic Conference on Synthetic Organic Chemistry session Natural Products Chemistry
DS Minerva
RD 23 abr 2026