RT Journal Article
T1 Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity
A1 Rodríguez Santos, Luis
A1 Costas, Celia
A1 Louzao Ojeda, María del Carmen
A1 Cagide, Eva
A1 Álvarez, Mercedes
A1 Rodríguez Cañás, Inés
A1 Raposo García, Sandra
A1 Vale González, María del Carmen
A1 Rodríguez Vieytes, Mercedes
A1 Lolo, Manuel
A1 Botana López, Luis Miguel
K1 Diarrhetic shellfish poisoning
K1 Okadaic acid
K1 Pharmacokinetic
K1 Voluntary feeding
AB The marine toxins of the Okadaic acid (OA) group are natural compounds produced by dinoflagellates that enters the food chain by accumulating in seafood. They are responsible for Diarrhetic Shellfish Poisoning (DSP) events in humans over the world and therefore are also jointly named as Diarrhetic Shellfish Toxins (DSTs). The main objective of this study was to evaluate symptoms, toxicity, absorption, distribution, and elimination of OA, Dinophysistoxin-1 (DTX1), and Dinophysistoxin-2 (DTX2) at the sublethal dose of 90 μg toxin/kg bw administered through voluntary feeding to mice. The toxin comparison highlighted that OA and DTX1 induced more severe and specific symptoms such as diarrhea. After oral ingestion toxins were distributed through the entire organism being detected in liver, kidney, stomach, small and large intestine. Predominant excretion of the toxins was observed in feces, with OA exhibiting fast elimination, while DTX2 was showing prolonged excretion. The passage and accumulation of toxins in gastrointestinal organs instigated macroscopic damage in the stomach, small and large intestine that could persist up to 120 h. These findings highlight the importance of pharmacokinetic of sublethal doses of DSTs administered by voluntary feeding in their toxicity and their implication for public health.
PB Elsevier
SN 0045-6535
YR 2024
FD 2024-09-28
LK https://hdl.handle.net/10347/39844
UL https://hdl.handle.net/10347/39844
LA eng
NO References  Rodríguez-Santos, L., Costas, C., Louzao, M. C., Cagide, E., Alvarez, M., Rodríguez-Cañás, I., Raposo-García, S., Vale, C., Vieytes, M. R., Lolo, M., & Botana, L. M. (2024). Bioavailability profiling shows differences in OA, DTX1 and DTX2 toxins that justify their toxicity. Chemosphere, 36610.1016/j.chemosphere.2024.143419
NO The research leading to these results has received funding from the following grants. From Conselleria de Cultura, Educacion e Ordenación Universitaria, Xunta de Galicia, GRC (ED431C 2021/01). From Ministerio de Ciencia e Innovación, Grant CPP2021-008447 funded by MCIN/AEI/10.13039/501100011033 and by The European Union NextGenerationEU/PRT, PID 2020-11262RB-C21. From Interreg EAPA-0032/2022 – BEAP-MAR (cofunded by the EU), from European Union HORIZON-MSCA-2022-DN-01-MSCA Doctoral Networks 2022 101119901-BIOTOXDoc, and HORIZON-CL6-2023-CIRCBIO-01 COMBO - 101135438.
DS Minerva
RD 5 may 2026