RT Journal Article
T1 First insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugs
A1 Lozano, Joao
A1 Cunha, Eva
A1 Carvalho, Luis M. Madeira de
A1 Paz Silva, Adolfo
A1 Oliveira, Manuela
K1 Gastrointestinal parasites
K1 Predatory fungi
K1 Mucor spp.
K1 Antiparasitic drugs
K1 Susceptibility
AB The combined application of predatory fungi and antiparasitic drugs is a sustainable approach for the integrated control of animal gastrointestinal (GI) parasites. However, literature addressing the possible interference of  antiparasitic drugs on the performance of these fungi is still scarce. This research aimed to assess the in vitro susceptibility of six native coccidicidal fungi isolates of the species Mucor circinelloides and one Mucor lusitanicusisolate to several antiparasitic drugs commonly used to treat GI parasites’ infections in birds, namely anthelminthics such as Albendazole, Fenbendazole, Levamisole and Ivermectin, and anticoccidials such as Lasalocid, Amprolium and Toltrazuril (drug concentrations of 0.0078–4 μg/mL), using 96-well microplates filled with RPMI 1640 medium, and also on Sabouraud Agar (SA). This research revealed that the exposition of all Mucor isolates to the tested anthelminthic and anticoccidial drug concentrations did not inhibit their growth. Fungal growth was recorded in RPMI medium, after 48 h of drug exposure, as well as on SA medium after exposure to the maximum drug concentration. Preliminary findings from this research suggest the potential compatibility of these Mucor isolates with antiparasitic drugs for the integrated control of avian intestinal parasites. However, further in vitro and in vivo studies are needed to confirm this hypothesis.
PB Springer Nature
SN 1746-6148
YR 2024
FD 2024-02-24
LK https://hdl.handle.net/10347/39105
UL https://hdl.handle.net/10347/39105
LA eng
NO Lozano, J., Cunha, E., de Carvalho, L.M. et al. First insights on the susceptibility of native coccidicidal fungi Mucor circinelloides and Mucor lusitanicus to different avian antiparasitic drugs. BMC Vet Res 20, 63 (2024). https://doi.org/10.1186/s12917-024-03909-z
DS Minerva
RD 22 abr 2026