RT Journal Article
T1 Intracellular deprotection reactions mediated by palladium complexes equipped with designed phosphine ligands
A1 Martínez-Calvo, Miguel
A1 Rodríguez Couceiro, José
A1 Destito, Paolo
A1 Rodríguez Villar, Jéssica
A1 Mosquera Mosquera, Jesús
A1 Mascareñas Cid, José Luis
K1 Bioorthogonal
K1 Discrete complexes
K1 Intracellular catalysis
K1 Mitochondrial confinement
K1 Palladium
AB Discrete palladium(II) complexes featuring purposely designed phosphine ligands can promote depropargylation and deallylation reactions in cell lysates. These complexes perform better than other palladium sources, which apparently are rapidly deactivated in such hostile complex media. This good balance between reactivity and stability allows the use of these discrete phosphine palladium complexes in living mammalian cells, whereby they can mediate similar transformations. The presence of a phosphine ligand in the coordination sphere of palladium also provides for the introduction of targeting groups, such as hydrophobic phosphonium moieties, which facilitate the accumulation of the complexes in mitochondria
PB American Chemical Society
YR 2018
FD 2018-06-01
LK http://hdl.handle.net/10347/16860
UL http://hdl.handle.net/10347/16860
LA eng
NO Martínez-Calvo, M., Couceiro, J., Destito, P., Rodríguez, J., Mosquera, J., & Mascareñas, J. (2018). Intracellular Deprotection Reactions Mediated by Palladium Complexes Equipped with Designed Phosphine Ligands. ACS Catalysis, 6055-6061. doi: 10.1021/acscatal.8b01606
NO We are thankful for the financial support from the Xunta de Galicia (Centro Singular de Investigación de Galicia Acreditación 2016–2019, ED431G/09) and the European Union (European Regional Development Fund–ERDF). We also thank support given by the Spanish Grant No. SAF2016-76689-R, the Xunta de Galicia (Grant Nos. 2015-CP082, ED431C 2017/19), and the European Research Council (Advanced Grant No. 340055). M.M.C. thanks the Ministerio de Economía y Competitividad for the Postdoctoral fellowship (No. IJCI-2014-19326). J.R. and J.M. thank Xunta de Galicia and Ministerio of Educacion, respectively, for predoctoral fellowships. The authors thank R. Menaya-Vargas for technical assistance
DS Minerva
RD 23 abr 2026